| TN1023 |
Miltirone
|
|
P450
,
GABA Receptor
|
|
Miltirone is a CYPs inhibitor, it has been characterized as a low-affinity ligand for central benzodiazepine receptors. |
| T5754 |
Kavain
|
|
NF-κB
,
GABA Receptor
|
|
Kavain, a compound extracted from the Kava plant, Piper methysticum, is found to be involved in TNF-α expression in human and mouse cells via regulation of transcriptional factors such as NF-kB and LITAF. |
| TQ0119 |
Cirsimaritin
|
|
GABA Receptor
|
|
|
| T0508 |
γ-Aminobutyric acid
|
Gamma-aminobutyric acid,4-Aminobutyric acid,GABA,4-Aminobutanoic acid,Piperidic acid |
GABA Receptor
,
Endogenous Metabolite
|
|
γ-Aminobutyric acid (4-Aminobutyric acid) is the most common inhibitory neurotransmitter in the central nervous system. |
| T3782 |
Jujuboside A
|
|
transporter
,
GABA Receptor
|
|
Jujuboside A is a glycoside extracted from Semen Ziziphi Spinosae, having neurophysiological inhibitory effects, used as a potential therapeutic agent for the treatment of Alzheimer s disease. |
| T7557 |
Guvacine hydrochloride
|
|
GABA Receptor
|
|
Guvacine hydrochloride is an inhibits of GABA uptake (IC50 : 10 μM) |
| T8036 |
6-Methylflavone
|
|
GABA Receptor
|
|
6-Methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors. |
| T3S2100 |
(-)-Securinine
|
Securinine |
GABA Receptor
|
|
(-)-Securinine (Securinine) is plant-derived alkaloid and also a GABAA receptor antagonist. |
| T5799 |
Arecaidine hydrochloride
|
|
Others
|
|
Arecaidine hydrochloride may have carcinogenesis. |
| TN1217 |
2'-O-Methylisoliquiritigenin
|
|
Dopamine Receptor
,
5-HT Receptor
,
GABA Receptor
|
|
2'-O-Methylisoliquiritigenin, a compound synthesized by enzymes specifically induced in NR.2'-O-Methylisoliquiritigenin, isolated from the Arachis species, up-regulates 5-HT, NE, DA and GABA pathways, but does not put a ... |
| T8268 |
6,2'-Dihydroxyflavone
|
|
GABA Receptor
|
|
6,2'-Dihydroxyflavone is a novel antagonist of GABAA receptor. |
| T2979 |
DL-Menthol
|
Hexahydrothymol,(±)-Menthol |
GABA Receptor
,
AChE
|
|
DL-Menthol ((±)-Menthol) is a racemic mixture of the monoterpene alcohols (–)-menthol and (+)-menthod, which have been found in Cannabis. (–)-Menthol is more common than (+)-menthol in nature and exhibits analgesic, anti... |
| T2850 |
Bicuculline
|
(+)-Bicuculline,d-Bicuculline |
GABA Receptor
|
|
Bicuculline ((+)-Bicuculline) is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungos... |
| T2749 |
Ginkgolide A
|
BN-52020 |
GABA Receptor
,
Endogenous Metabolite
|
|
Ginkgolide A (BN-52020) is a highly active PAF antagonist cage molecule that is isolated from the leaves of the Ginkgo biloba tree. Shows potential in a wide variety of inflammatory and immunological disorders. |
| T2S1464 |
Thiocolchicoside
|
Thiocolchicine 2-glucoside analog,Coltramyl |
Others
,
GABA Receptor
|
|
Thiocolchicoside (Thiocolchicine 2-glucoside analog) (Muscoril, Myoril, Neoflax) is a muscle relaxant with anti-inflammatory and analgesic effects. It acts as a competitive GABAA receptor antagonist and also glycine rece... |
| T1396 |
Bemegride
|
Bemegrid,3-Ethyl-3-methylglutarimide,Agipnon |
GABA Receptor
|
|
Bemegride (3-Ethyl-3-methylglutarimide), a central nervous system stimulant, serves as an antidote for barbiturate poisoning. |
| T2720 |
Ginsenoside Rc
|
Panaxoside Rc |
Others
,
TNF
,
GABA Receptor
,
Interleukin
|
|
Ginsenoside Rc (Panaxoside Rc) is one of the ginsenosides from Panax ginseng, inhibits the expression of TNF-α and IL-1β. |
| T3698 |
Alpha-Asarone
|
α-Asarone,trans-Asarone |
P450
,
GABA Receptor
,
HMG-CoA Reductase
|
|
alpha-Asarone (trans-Asarone) is a psychoactive compound with antidepressant-like activity in mice. |
| T4728 |
4-Acetamidobutanoic acid
|
N-acetyl GABA,4-ACETAMIDOBUTYRIC ACID |
GABA Receptor
,
Endogenous Metabolite
,
Antibacterial
|
|
4-Acetamidobutanoic acid (4-ACETAMIDOBUTYRIC ACID) can be found in blood, feces, and urine, as well as in human prostate tissue. 4-Acetamidobutanoic acid exists in all eukaryotes, ranging from yeast to humans. 4-Acetamid... |
| T5S1882 |
Songorine
|
Napellonine,Zongorine,Bullatine G |
Others
,
GABA Receptor
|
|
Songorine (Napellonine) shows favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays. |
| TMS0418 |
Dihydroergotoxine mesylate
|
Ergoloid mesylates |
GABA Receptor
|
|
Dihydroergotoxine mesylate (Ergoloid mesylates) is mainly used to improve symptoms and physical symptoms of mental degeneration related to aging. |
| T2983 |
3,4,5-Trimethoxycinnamic acid
|
3-(3,4,5-Trimethoxyphenyl)acrylic Acid,O-Methylsinapic acid |
GABA Receptor
,
Endogenous Metabolite
|
|
3,4,5-Trimethoxycinnamic acid (O-Methylsinapic acid) (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA/BZ receptor complex. |
| TN1202 |
(-)-α-Pinene
|
(1S)-(-)-Alpha-Pinene |
Virus Protease
,
GABA Receptor
,
Endogenous Metabolite
,
Antibacterial
|
|
(-)-α-Pinene ((1S)-(-)-Alpha-Pinene) enhances the quantity of NREMS without affecting the intensity of NREMS by prolonging GABAergic synaptic transmission, acting as a partial modulator of GABAA-BZD receptors and directl... |
| T7595 |
L-DABA
|
L-2,4-Diaminobutyric acid,L-DAB HBR |
GABA Receptor
,
Endogenous Metabolite
|
|
L-DABA (L-2,4-Diaminobutyric acid) is an inhibitor of GABA transaminase (IC50 > 500 μM). |
| T4590 |
(+)-Kavain
|
Kavain,L-KAWAIN,(R)-KAWAIN |
Calcium Channel
,
GABA Receptor
,
Sodium Channel
,
Monoamine Transporter
|
|
(+)-Kavain ((R)-KAWAIN) is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B. |
| TN2865 |
(E)-3,4,5-Trimethoxycinnamic acid
|
O-Methylsinapic acid,3,4,5-Trimethoxy-trans-cinnamic acid,3,4,5-Trimethoxyphenylacrylic acid |
Others
|
|
(E)-3,4,5-Trimethoxycinnamic acid (O-Methylsinapic acid) is a natural product from the roots and rhizomes of Notopterygium incisum. |
| TN1325 |
(2S)-6-Prenylnaringenin
|
6-Prenylnaringenin,6-PN |
GABA Receptor
|
|
(2S)-6-Prenylnaringenin (6-Prenylnaringenin) is an isomer of the potent phytoestrogen, 8-prenylnaringenin. (2S)-6-Prenylnaringenin is the most potent compound in the forebrain and acts as a positive allosteric modulator ... |
| T8040 |
Cholesterol myristate
|
Cholesteryl myristate,Cholesteryl tetradecanoate |
Others
,
Potassium Channel
,
GABA Receptor
,
Endogenous Metabolite
,
AChR
|
|
Cholesterol Myristate (Cholesteryl Myristate) is a natural steroid found in traditional Chinese medicine that interacts with various ion channels, including the GABAA receptor, nicotinic acetylcholine receptor, and the i... |
| T2S1814 |
P-Hydroxybenzaldehyde
|
4-Formylphenol,4-hydroxybenzaldehyde,p-Oxybenzaldehyde |
Transaminase
,
GABA Receptor
,
Endogenous Metabolite
|
|
1. p-Hydroxybenzaldehyde (p-Oxybenzaldehyde) shows an inhibitory effect on the GABA transaminase to contribute to an antiepileptic and anticonvulsive activity, and its inhibitory activity was higher than that of valproic... |
| T8193 |
α-Thujone
|
Thujone,ALPHA-(-)-THUJONE |
Apoptosis
,
Reactive Oxygen Species
,
GABA Receptor
,
AChR
,
Parasite
,
Autophagy
|
|
α-Thujone is an inhibitor of ACh with an IC50 value of 24.7μM. |
| T0710 |
L-Cycloserine
|
Levcycloserine,Levcicloserina,(-)-Cycloserine,(S)-Cycloserine,Levcycloserinum,(S)-4-Amino-3-isoxazolidone |
HIV Protease
,
GABA Receptor
|
|
L-Cycloserine ((-)-Cycloserine) irreversibly inhibits GABA pyridoxal 5′-phosphate-dependent aminotransferase in E. coli, as well in the brains of various animals, results in increased levels of gamma-aminobutyric acid (G... |
| T3417 |
Amentoflavone
|
Didemethyl-ginkgetin,Amenthoflavone,3',8''-Biapigenin |
Apoptosis
,
P450
,
Phospholipase
,
Reactive Oxygen Species
,
Opioid Receptor
,
COX
,
Antibacterial
,
RSV
,
Antifungal
|
|
Amentoflavone (3',8''-Biapigenin), as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhib... |
| TCS0102 |
Pulegone
|
(+)-Pulegone |
Calcium Channel
,
Endogenous Metabolite
,
TRP/TRPV Channel
|
|
1. Pulegone ((+)-Pulegone) has cytotoxicity followed by regenerative cell proliferation is the MOA for Pulegone-induced urothelial tumors in female rats. 2. Pulegone induces a verapamil-sensitive psychostimulant effect t... |
